Pyrimidine Catabolism : UMP and CMP degradation Pathway

Animal cells degrade pyrimidine nucleotides (Pyrimidine Catabolism Pathway) to their component bases. These reactions, like those of purine nucleotides, occur through Dephosphorylation, Deamination and Glycosidic bond cleavages. After Pyrimidine biosynthesis, the newly synthesized molecules undergoes degradation after certain period. Table of Contents Pyrimidine Catabolism Steps:Step 1:Step 2:Step 3:Step 4:Step 5:Step 6:Step 7:Step 8:Conclusion: Pyrimidine Catabolism […]

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  • March 19, 2016

Purine Catabolism and its Uric Acid formation

Purine catabolism pathway is one of the Nucleic acid Metabolism. Because nucleic acids are ubiquitous in cellular material, significant amounts are ingested in the diet. Nucleic acids are degraded in the digestive tract to nucleotides by various nucleases and phosphodiesterases. Nucleotides are then converted to nucleosides by base-specific nucleotidases and nonspecific phosphatases.           Nucleosides are hydrolyzed […]

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  • Updated April 12, 2019

Purine Synthesis : Synthesis of Purine RiboNucleotides

In 1948 “John Buchanor” obtains the first clues as to how this process occurs. Denovo by feeding a variety of isotopically labeled compounds to pigeons and chemically determining the position of the labeled atoms in their excreted Uric acid. The results of the studies are Purine synthesis. Nucleic Acids are the Molecular Language of life […]

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  • Updated April 12, 2019

What are the Fate of Pyruvate Molecules after Glycolysis?

Glycolysis is taking place in Cytoplasm. So Pyruvate is generated in Cytoplasm. This is to be transported into mitochondria by a Pyruvate transporter. It is a simport, where the hydrogen ion is a transporter. Here two different enzymes are involved based on the condition. They are Pyruvate dehydrogenase and Lactate dehydrogenase enzymes. There are 2 […]

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  • Updated April 12, 2019

Biochemist: Analysis of biochemistry Career

Biochemistry is a scientific discipline and the study of chemical reactions in organisms. It is a field of laboratory medicine, including neuropathology, hematopathology, and the microbiology. Biochemists are specialists who study the origin, nature, reason and the development of human diseases including Molecular biology. In simple terms, Biochemists are scientists trained om Biochemistry. Table of […]

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  • Updated April 12, 2019