Category Archives for "Intermediary Metabolism"

Phenylketonuria (PKU): What is PKU and its Treatment

In the United States, each year about 1 in 10,000 to 15,000 babies is born with PKU. This disease occurs in all ethnic groups. But it is most common in Native Americans and northern Europeans in African Americans, or Japanese in Ashkenazi Jews. What causes PKU? PKU is inherited. That means it is passed from parents to children […]

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Pyrimidine Synthesis Pathway: Synthesis of pyrimidine derivatives

The pyrimidine synthesis is a similar process than that of Purines(Purines Synthesis). In the de novo synthesis of Pyrimidines, the ring is synthesized first and then it is attached to a ribose-phosphate to for a pyrimidine nucleotide. Pyrimidine rings are assembled from bicarbonate, aspartate and Ammonia. The pyrimidine biosynthesis (de novo pyrimidine synthesis pathway) was […]

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Heme Synthesis : Synthesis of Porphyrin Molecule

Heme is a Porphyrin molecule. The porphyrins found in nature are compounds in which various side chains are substituted for the 8 hydrogen atoms numbered in Porphin nucleus. This notes explain about Heme synthesis in animals and plants. What is the Composition of Blood ? What happens to Blood Sugar after a Meal? Plasma Proteins: […]

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Pyrimidine Catabolism : UMP and CMP degradation Pathway

Animal cells degrade pyrimidine nucleotides (Pyrimidine Catabolism Pathway) to their component bases. These reactions, like those of purine nucleotides, occur through Dephosphorylation, Deamination and Glycosidic bond cleavages. After Pyrimidine biosynthesis, the newly synthesized molecules undergoes degradation after certain period. Pyrimidine Catabolism Steps: The catabolism of pyrimidine nucleotides are explained in few steps. Step 1: CMP, […]

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