Category Archives for "Biological Oxidation"

Antioxidants and their protective role against free radicals

Survey of literature indicates that each of the 60 trillion cells in the human body take 10,000 oxidative hits/sec due to the production of harmful molecules called free radicals. Free radicals are chemically active atoms (groups of atoms) or molecular fragments that have a charge due to an excess or deficient number of electrons. Free […]

Continue reading

Chemiosmotic Theory by ATP Synthase Complex

ATP is synthesized by ATP Synthase, which is an enzyme complex made of a proton-conducting F­­0 unit and a catalyst F1 unit. The mitochondrial inner membrane contains the ATP synthesizing enzyme complex called ‘ATP synthase’(or) ‘F0 F1-ATPase’. (F for factor). F1 component is like a “door-knob” protruding into the matrix from the inner membrane. It […]

Continue reading

Inhibitors and UnCouplers of Oxidative Phosphorylation

Ability to harness energy from external sources and utilize it for biological work is characteristic of all living organisms. Phototrophs harvest the energy of light (Plants). Chemotrophs harvest energy from oxidation of fuel molecules.  The oxidation of foodstuffs occurs in three stages. Oxidative Stages of Food Stuff: 1. Primary Metabolism: In the first stage, DIGESTION […]

Continue reading

Oxidative Phosphorylation: Fate of Electrons in Mitochondria

The coupling of oxidation with phosphorylation is termed “Oxidative phosphorylation”, which takes place during the electron transport in the inner membrane. DEFINITION: What is the definition of Oxidative Phosphorylation. The Endergonic synthesis of ATP from ADP and pi in mitochondria is called “Oxidative phosporylation”, which is catalyzed by the enzyme “ATP synthase” (or) “mitochondrial ATPase […]

Continue reading