Category Archives for "Nucleoteide Metabolism"

Pyrimidine Synthesis Pathway: Synthesis of pyrimidine derivatives

The pyrimidine synthesis is a similar process than that of Purines(Purines Synthesis). In the de novo synthesis of Pyrimidines, the ring is synthesized first and then it is attached to a ribose-phosphate to for a pyrimidine nucleotide. Pyrimidine rings are assembled from bicarbonate, aspartate and Ammonia. The pyrimidine biosynthesis (de novo pyrimidine synthesis pathway) was […]

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Pyrimidine Catabolism : UMP and CMP degradation Pathway

Animal cells degrade pyrimidine nucleotides (Pyrimidine Catabolism Pathway) to their component bases. These reactions, like those of purine nucleotides, occur through Dephosphorylation, Deamination and Glycosidic bond cleavages. After Pyrimidine biosynthesis, the newly synthesized molecules undergoes degradation after certain period. Pyrimidine Catabolism Steps: The catabolism of pyrimidine nucleotides are explained in few steps. Step 1: CMP, […]

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Purine Catabolism and its Uric Acid formation

Purine catabolism pathway is one of the Nucleic acid Metabolism. Because nucleic acids are ubiquitous in cellular material, significant amounts are ingested in the diet. Nucleic acids are degraded in the digestive tract to nucleotides by various nucleases and phosphodiesterases. Nucleotides are then converted to nucleosides by base-specific nucleotidases and nonspecific phosphatases.           Nucleosides are hydrolyzed […]

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Purine Synthesis : Synthesis of Purine RiboNucleotides

In 1948 “John Buchanor” obtains the first clues as to how this process occurs. Denovo by feeding a variety of isotopically labeled compounds to pigeons and chemically determining the position of the labeled atoms in their excreted Uric acid. The results of the studies are Purine synthesis. Nucleic Acids are the Molecular Language of life […]

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